# Sachs (2005) protein signaling data — `Sachs2005.txt`

## Citation

If you use these measurements, cite the original study:

> Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D. A., & Nolan, G. P. (2005). Causal protein-signaling networks derived from multiparameter single-cell data. *Science*, *308*(5721), 523–529.  
> DOI: [10.1126/science.1105809](https://doi.org/10.1126/science.1105809)

BibTeX:

```bibtex
@article{Sachs2005,
  author  = {Sachs, Karen and Perez, Omar and Pe'er, Dana and Lauffenburger, Douglas A. and Nolan, Garry P.},
  title   = {Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data},
  journal = {Science},
  year    = {2005},
  volume  = {308},
  number  = {5721},
  pages   = {523--529},
  doi     = {10.1126/science.1105809}
}
```

## License and redistribution

The flow cytometry measurements are from Sachs et al. (2005) and the associated *Science* article and supplementary materials.

**The MIT License in the root of this repository applies to the project’s own code only, not to this third-party benchmark file.** The authors of this repository do not assert a separate open license on the Sachs data; if you redistribute the file or publish work that uses it, follow the policies of the original publication, any data-use agreements you accepted when obtaining the file, and your institution’s requirements, and cite the paper above.

## Use in this repository

- **File:** `exp/Sachs2005.txt` (tab-separated continuous values, 11 protein / lipid columns).
- **Notebook:** `causal_comp_analysis_application.ipynb` (Experiment 2).